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Directeur de Recherche

Deputy Scientific Director of INRIA for Digital Health, Biology and Earth.

Research

I am working in computational cell biology, the use of computer or mathematical models to study intra-cellular dynamics. Currently, I am focusing on :

(i) the intracellular biochemical networks at work in synaptic plasticity and its modulation, in particular by astrocytes.

(ii) the influence of space and molecular crowding in cell signaling and biochemistry.

Our INRIA team, Beagle, is also co-affiliated with the LIRIS laboratory (UMR 5205 CNRS - INSA Lyon - Univ. Lyon 1).


Keywords

Computational neuroscience:

Astrocyte-Neurons co-culture
  • Glia-neuron interactions
  • Intracellular calcium signalling in astrocytes
  • Modelling intrinsic and synaptic plasticity

Intracellular organization of cell signaling:

  • Molecular crowding and spatial inhomogeneities in biochemical reactions
  • Protein agregation in bacterial cells
Spatial Effects of Molecular Crowding